Imbalance of Neocortical Excitation and Inhibition and Altered UP States Reflect Network Hyperexcitability in the Mouse Model of Fragile X Syndrome

Despite the pronounced neurological deficits associated with mental retardation and autism, it is unknown if altered neocortical circuit function occurs in these prevalent disorders. Here we demonstrate specific alterations in local synaptic connections, membrane excitability, and circuit activity o...

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Huvudupphovsmän: Gibson, Jay R., Bartley, Aundrea F., Hays, Seth A., Huber, Kimberly M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2008
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585391/
https://ncbi.nlm.nih.gov/pubmed/18784272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.90752.2008
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