APP Causes Hyperexcitability in Fragile X Mice

Amyloid-beta protein precursor (APP) and metabolite levels are altered in fragile X syndrome (FXS) patients and in the mouse model of the disorder, Fmr1(KO) mice. Normalization of APP levels in Fmr1(KO) mice (Fmr1(KO)/APP(HET) mice) rescues many disease phenotypes. Thus, APP is a potential biomarker...

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Dades bibliogràfiques
Publicat a:Front Mol Neurosci
Autors principals: Westmark, Cara J., Chuang, Shih-Chieh, Hays, Seth A., Filon, Mikolaj J., Ray, Brian C., Westmark, Pamela R., Gibson, Jay R., Huber, Kimberly M., Wong, Robert K. S.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2016
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5156834/
https://ncbi.nlm.nih.gov/pubmed/28018172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2016.00147
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