Soluble epoxide hydrolase gene deletion reduces survival after cardiac arrest and cardiopulmonary resuscitation

SUMMARY: The P450 eicosanoids epoxyeicosatrienoic acids (EETs) are produced by cytochrome P450 arachidonic acid epoxygenases and metabolized through multiple pathways, including soluble epoxide hydrolase (sEH). Pharmacological inhibition and gene deletion of sEH protect against ischemia/reperfusion...

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Detalhes bibliográficos
Main Authors: Hutchens, Michael P., Nakano, Takaaki, Dunlap, Jennifer, Traystman, Richard J., Hurn, Patricia D., Alkayed, Nabil J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585367/
https://ncbi.nlm.nih.gov/pubmed/17728042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.resuscitation.2007.06.031
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