Peptide P5 (residues 628–683), comprising the entire membrane proximal region of HIV-1 gp41 and its calcium-binding site, is a potent inhibitor of HIV-1 infection

The membrane proximal region (MPR) of the transmembrane subunit, gp41, of the HIV envelope glycoprotein plays a critical role in HIV-1 infection of CD4(+) target cells and CD4-independent mucosal entry. It contains continuous epitopes recognized by neutralizing IgG antibodies 2F5, 4E10 and Z13, and...

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Bibliographische Detailangaben
Hauptverfasser: Yu, Huifeng, Tudor, Daniela, Alfsen, Annette, Labrosse, Beatrice, Clavel, François, Bomsel, Morgane
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2008
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585100/
https://ncbi.nlm.nih.gov/pubmed/18925934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-5-93
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