Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress

Cardiac defects associated with increased pulmonary blood flow result in pulmonary vascular dysfunction that may relate to a decrease in bioavailable nitric oxide (NO). An 8-mm graft (shunt) was placed between the aorta and pulmonary artery in 30 late gestation fetal lambs; 27 fetal lambs underwent...

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Main Authors: Oishi, Peter E., Wiseman, Dean A., Sharma, Shruti, Kumar, Sanjiv, Hou, Yali, Datar, Sanjeev A., Azakie, Anthony, Johengen, Michael J., Harmon, Cynthia, Fratz, Sohrab, Fineman, Jeffrey R., Black, Stephen M.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584884/
https://ncbi.nlm.nih.gov/pubmed/18757524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00146.2007
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