Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence

BACKGROUND: Cellular senescence is a state reached by normal mammalian cells after a finite number of cell divisions and is characterized by morphological and physiological changes including terminal cell-cycle arrest. The limits on cell division imposed by senescence may play an important role in b...

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Bibliographic Details
Main Authors: Nakamura, Asako J, Chiang, Y Jeffrey, Hathcock, Karen S, Horikawa, Izumi, Sedelnikova, Olga A, Hodes, Richard J, Bonner, William M
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584625/
https://ncbi.nlm.nih.gov/pubmed/19014415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8935-1-6
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