PD-1 ligand expression by human colonic myofibroblasts/fibroblasts regulates CD4(+) T cell activity

BACKGROUND & AIMS: A prominent role for inhibitory molecules PD-L1 and PD-L2 in peripheral tolerance has been proposed. However, the phenotype and function of PD-L-expressing cells in human gut remains unclear. Recent studies suggest that intestinal myofibroblasts (CMFs) and fibroblasts are impo...

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Hauptverfasser: Pinchuk, Irina V., Saada, Jamal I., Beswick, Ellen J., Boya, Gushyalatha, Qiu, Sumin M., Mifflin, Randy C., Raju, Gottumukkala S., Reyes, Victor E., Powell, Don W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584612/
https://ncbi.nlm.nih.gov/pubmed/18760278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2008.07.016
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