Human Colonic Myofibroblasts Promote Expansion of CD4+ CD25(high) Foxp3+ Regulatory T Cells

BACKGROUND & AIMS: Regulatory T (Treg) cells (CD4+ CD25(high) FoxP3+) regulate mucosal tolerance; their adoptive transfer prevents or reduces symptoms of colitis in mouse models of inflammatory bowel disease (IBD). T-cell functions are regulated by mesenchymal cells. Colonic CD90(+) mesenchymal...

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Main Authors: Pinchuk, Irina V., Beswick, Ellen J., Saada, Jamal I., Boya, Gushyalatha, Schmitt, David, Raju, Gottumukkala S., Brenmoehl, Julia, Rogler, Gerhard, Reyes, Victor E., Powell, Don W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109194/
https://ncbi.nlm.nih.gov/pubmed/21376048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.02.059
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