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Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150(Glued) subunit of dynactin

An increasing number of neurodegenerative diseases are being linked to mutations in genes encoding proteins required for axonal transport and intracellular trafficking. A mutation in p150(Glued), a component of the cytoplasmic dynein/dynactin microtubule motor complex, results in the human neurodege...

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Bibliographic Details
Main Authors: Chevalier-Larsen, Erica S., Wallace, Karen E., Pennise, Cynthia R., Holzbaur, Erika L.F.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584350/
https://ncbi.nlm.nih.gov/pubmed/18364389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn092
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