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Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

OBJECTIVE—To establish the mechanism of the phenotypic switch of adipose tissue macrophages (ATMs) from an alternatively activated (M2a) to a classically activated (M1) phenotype with obesity. RESEARCH DESIGN AND METHODS—ATMs from lean and obese (high-fat diet–fed) C57Bl/6 mice were analyzed by a co...

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Hlavní autoři: Lumeng, Carey N., DelProposto, Jennifer B., Westcott, Daniel J., Saltiel, Alan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584129/
https://ncbi.nlm.nih.gov/pubmed/18829989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0872
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