Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

OBJECTIVE—To establish the mechanism of the phenotypic switch of adipose tissue macrophages (ATMs) from an alternatively activated (M2a) to a classically activated (M1) phenotype with obesity. RESEARCH DESIGN AND METHODS—ATMs from lean and obese (high-fat diet–fed) C57Bl/6 mice were analyzed by a co...

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Bibliographic Details
Main Authors: Lumeng, Carey N., DelProposto, Jennifer B., Westcott, Daniel J., Saltiel, Alan R.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2008
Subjects:
Obesity Studies
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584129/
https://ncbi.nlm.nih.gov/pubmed/18829989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0872
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