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Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

OBJECTIVE—To establish the mechanism of the phenotypic switch of adipose tissue macrophages (ATMs) from an alternatively activated (M2a) to a classically activated (M1) phenotype with obesity. RESEARCH DESIGN AND METHODS—ATMs from lean and obese (high-fat diet–fed) C57Bl/6 mice were analyzed by a co...

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書誌詳細
主要な著者: Lumeng, Carey N., DelProposto, Jennifer B., Westcott, Daniel J., Saltiel, Alan R.
フォーマット: Artigo
言語:Inglês
出版事項: American Diabetes Association 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584129/
https://ncbi.nlm.nih.gov/pubmed/18829989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0872
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