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Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

OBJECTIVE—To establish the mechanism of the phenotypic switch of adipose tissue macrophages (ATMs) from an alternatively activated (M2a) to a classically activated (M1) phenotype with obesity. RESEARCH DESIGN AND METHODS—ATMs from lean and obese (high-fat diet–fed) C57Bl/6 mice were analyzed by a co...

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書目詳細資料
Main Authors: Lumeng, Carey N., DelProposto, Jennifer B., Westcott, Daniel J., Saltiel, Alan R.
格式: Artigo
語言:Inglês
出版: American Diabetes Association 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584129/
https://ncbi.nlm.nih.gov/pubmed/18829989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0872
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