Upregulation of Mitochondrial Uncoupling Protein-2 by the AMP-Activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes

OBJECTIVE—Recent evidence suggests that the AMP-activated protein kinase (AMPK) is an important therapeutic target for diabetes. The present study was conducted to determine how AMPK activation suppressed tyrosine nitration of prostacyclin synthase in diabetes. RESEARCH DESIGN AND METHODS—Confluent...

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Detalhes bibliográficos
Main Authors: Xie, Zhonglin, Zhang, Junhua, Wu, Jiliang, Viollet, Benoit, Zou, Ming-Hui
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2008
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584127/
https://ncbi.nlm.nih.gov/pubmed/18835932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0610
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