Activation of AMP-activated Protein Kinase by Vascular Endothelial Growth Factor Mediates Endothelial Angiogenesis Independently of Nitric-oxide Synthase

AMP-activated protein kinase (AMPK) is a sensor of cellular energy state and a regulator of cellular homeostasis. In endothelial cells, AMPK is stimulated via the upstream kinases LKB1 and Ca(2+)/calmodulin-dependent protein kinase kinase β (CaMKKβ). Previously, AMPK has been reported to activate en...

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Bibliographic Details
Main Authors: Stahmann, Nadine, Woods, Angela, Spengler, Katrin, Heslegrave, Amanda, Bauer, Reinhard, Krause, Siegfried, Viollet, Benoit, Carling, David, Heller, Regine
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856272/
https://ncbi.nlm.nih.gov/pubmed/20129920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.108688
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