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Biochemical and Biophysical Characterization of a Chimeric TRIM21-TRIM5α Protein

The tripartite motif (TRIM) protein, TRIM5α, is an endogenous factor in primates that recognizes the capsids of certain retroviruses after virus entry into the host cell. TRIM5α promotes premature uncoating of the capsid, thus blocking virus infection. Low levels of expression and tendencies to aggr...

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Autori principali: Kar, Alak Kanti, Diaz-Griffero, Felipe, Li, Yuan, Li, Xing, Sodroski, Joseph
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583655/
https://ncbi.nlm.nih.gov/pubmed/18799572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01559-08
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