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Experimental Evolution of Human Influenza Virus H3 Hemagglutinin in the Mouse Lung Identifies Adaptive Regions in HA1 and HA2

The genetic basis for virulence and host switching in influenza A viruses (FLUAV) is largely unknown. Because the hemagglutinin (HA) protein is a determinant of these properties, HA evolution was mapped in an experimental model of mouse lung adaptation. Variants of prototype A/Hong Kong/1/68 (H3N2)...

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Detalhes bibliográficos
Main Authors: Keleta, Liya, Ibricevic, Aida, Bovin, Nicolai V., Brody, Steven L., Brown, Earl G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583651/
https://ncbi.nlm.nih.gov/pubmed/18829764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01393-08
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