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Primary Activation of Antigen-Specific Naive CD4(+) and CD8(+) T Cells following Intranasal Vaccination with Recombinant Bacteria

The primary activation of T-helper and T-cytotoxic cells following mucosal immunization with recombinant Streptococcus gordonii was studied in vivo by adoptive transfer of ovalbumin (OVA)-specific transgenic CD8(+) (OT-I) and CD4(+) (OT-II) T cells. A recombinant strain, expressing on the surface th...

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Autors principals: Ciabattini, Annalisa, Pettini, Elena, Andersen, Peter, Pozzi, Gianni, Medaglini, Donata
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583588/
https://ncbi.nlm.nih.gov/pubmed/18838521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00793-08
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