A Novel Inhibitor of STAT3 Activation Is Efficacious Against Established Central Nervous System Melanoma and Inhibits Regulatory T Cells

PURPOSE: Activation of STAT3 has been identified as a central mediator of melanoma growth and metastasis. We hypothesized that WP1066, a novel STAT3 blockade agent, has marked antitumor activity, even against the melanoma metastasis to brain, a site typically refractory to therapies. EXPERIMENTAL DE...

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Main Authors: Kong, Ling-Yuan, Abou-Ghazal, Mohamed K., Wei, Jun, Chakraborty, Arup, Sun, Wei, Qiao, Wei, Fuller, Gregory N., Fokt, Izabela, Grimm, Elizabeth A., Schmittling, Robert J., Archer, Gary E., Sampson, John H., Priebe, Waldemar, Heimberger, Amy B.
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583362/
https://ncbi.nlm.nih.gov/pubmed/18794085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0377
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