Coordinating the Initial Steps of Base Excision Repair: APURINIC/APYRIMIDINIC ENDONUCLEASE 1 ACTIVELY STIMULATES THYMINE DNA GLYCOSYLASE BY DISRUPTING THE PRODUCT COMPLEX

DNA glycosylases initiate base excision repair by removing damaged or mismatched bases, producing apurinic/apyrimidinic (AP) DNA. For many glycosylases, the AP-DNA remains tightly bound, impeding enzymatic turnover. A prominent example is thymine DNA glycosylase (TDG), which removes T from G·T mispa...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Fitzgerald, Megan E., Drohat, Alexander C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2008
Gaiak:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583297/
https://ncbi.nlm.nih.gov/pubmed/18805789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805504200
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