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Coordinating the Initial Steps of Base Excision Repair: APURINIC/APYRIMIDINIC ENDONUCLEASE 1 ACTIVELY STIMULATES THYMINE DNA GLYCOSYLASE BY DISRUPTING THE PRODUCT COMPLEX
DNA glycosylases initiate base excision repair by removing damaged or mismatched bases, producing apurinic/apyrimidinic (AP) DNA. For many glycosylases, the AP-DNA remains tightly bound, impeding enzymatic turnover. A prominent example is thymine DNA glycosylase (TDG), which removes T from G·T mispa...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2583297/ https://ncbi.nlm.nih.gov/pubmed/18805789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805504200 |
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