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Targeted ablation of beta cells in the embryonic zebrafish pancreas using E.coli nitroreductase
In order to generate a zebrafish model of β cell regeneration, we have expressed an E.coli gene called nfsB in the β cells of embryonic zebrafish. This bacterial gene encodes a nitroreductase (NTR) enzyme, which can convert prodrugs such as metronidazole (Met) to cytotoxins. By fusing nfsB to mCherr...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2583263/ https://ncbi.nlm.nih.gov/pubmed/17223324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mod.2006.11.005 |
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