Decreased ER-associated degradation of α-TCR induced by Grp78 depletion with the SubAB cytotoxin

HeLa cells stably expressing the α chain of T-cell receptor (αTCR), a model substrate of ERAD (ER-associated degradation), were used to analyze the effects of BiP/Grp78 depletion by the SubAB cytotoxin. SubAB induced XBP1 splicing, followed by JNK phosphorylation, eIF2α phosphorylation, upregulation...

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Hauptverfasser: Lass, Agnieszka, Kujawa, Marek, McConnell, Elizabeth, Paton, Adrienne W., Paton, James C., Wójcik, Cezary
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583149/
https://ncbi.nlm.nih.gov/pubmed/18611445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2008.06.003
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