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Decreased ER-associated degradation of α-TCR induced by Grp78 depletion with the SubAB cytotoxin
HeLa cells stably expressing the α chain of T-cell receptor (αTCR), a model substrate of ERAD (ER-associated degradation), were used to analyze the effects of BiP/Grp78 depletion by the SubAB cytotoxin. SubAB induced XBP1 splicing, followed by JNK phosphorylation, eIF2α phosphorylation, upregulation...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2583149/ https://ncbi.nlm.nih.gov/pubmed/18611445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2008.06.003 |
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