A Structural Model of the Staphylococcus aureus ClfA–Fibrinogen Interaction Opens New Avenues for the Design of Anti-Staphylococcal Therapeutics

The fibrinogen (Fg) binding MSCRAMM Clumping factor A (ClfA) from Staphylococcus aureus interacts with the C-terminal region of the fibrinogen (Fg) γ-chain. ClfA is the major virulence factor responsible for the observed clumping of S. aureus in blood plasma and has been implicated as a virulence fa...

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Main Authors: Ganesh, Vannakambadi K., Rivera, Jose J., Smeds, Emanuel, Ko, Ya-Ping, Bowden, M. Gabriela, Wann, Elisabeth R., Gurusiddappa, Shivasankarappa, Fitzgerald, J. Ross, Höök, Magnus
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582960/
https://ncbi.nlm.nih.gov/pubmed/19043557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000226
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