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Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia

Fibrinogen can support host antimicrobial containment/clearance mechanisms, yet selected pathogens appear to benefit from host procoagulants to drive bacterial virulence. Here, we explored the hypothesis that host fibrin(ogen), on balance, supports Staphylococcus aureus infection in the context of s...

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Detalhes bibliográficos
Main Authors: Flick, Matthew J., Du, XinLi, Prasad, Joni M., Raghu, Harini, Palumbo, Joseph S., Smeds, Emanuel, Höök, Magnus, Degen, Jay L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591798/
https://ncbi.nlm.nih.gov/pubmed/23299312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-09-453894
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