Disruption of Nrf2, a Key Inducer of Antioxidant Defenses, Attenuates ApoE-Mediated Atherosclerosis in Mice

BACKGROUND: Oxidative stress and inflammation are two critical factors that drive the formation of plaques in atherosclerosis. Nrf2 is a redox-sensitive transcription factor that upregulates a battery of antioxidative genes and cytoprotective enzymes that constitute the cellular response to oxidativ...

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Bibliografische gegevens
Hoofdauteurs: Sussan, Thomas E., Jun, Jonathan, Thimmulappa, Rajesh, Bedja, Djahida, Antero, Maria, Gabrielson, Kathleen L., Polotsky, Vsevolod Y., Biswal, Shyam
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2008
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582492/
https://ncbi.nlm.nih.gov/pubmed/19023427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003791
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