MTHFR 677C → T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val → Met

Understanding how risk genes cumulatively impair brain function in schizophrenia could provide critical insights into its pathophysiology. Working memory impairment in schizophrenia has been associated with abnormal dopamine signaling in the prefrontal cortex, which is likely under complex genetic c...

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Bibliografski detalji
Glavni autori: Roffman, Joshua L., Gollub, Randy L., Calhoun, Vince D., Wassink, Thomas H., Weiss, Anthony P., Ho, Beng C., White, Tonya, Clark, Vincent P., Fries, Jill, Andreasen, Nancy C., Goff, Donald C., Manoach, Dara S.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582272/
https://ncbi.nlm.nih.gov/pubmed/18988738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803727105
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