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Hmga2 promotes neural stem cell self-renewal in young, but not old, mice by reducing p16(Ink4a) and p19(Arf) expression
Stem cells persist throughout life in diverse tissues by undergoing self-renewing divisions. Self-renewal capacity declines with age, partly due to increasing p16(Ink4a) expression, but little is known about the mechanisms responsible for these changes. We discovered the Hmga2 transcriptional regula...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2582221/ https://ncbi.nlm.nih.gov/pubmed/18957199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.09.01 |
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