BCR-ABL-transformed GMP as myeloid leukemic stem cells

During blast crisis of chronic myelogenous leukemia (CML), abnormal granulocyte macrophage progenitors (GMP) with nuclear β-catenin acquire self-renewal potential and may function as leukemic stem cells (Jamieson et al. N Engl J Med, 2004). To develop a mouse model for CML-initiating GMP, we express...

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Hauptverfasser: Minami, Yosuke, Stuart, Scott A., Ikawa, Tomokatsu, Jiang, Yong, Banno, Asoka, Hunton, Irina C., Young, Dennis J., Naoe, Tomoki, Murre, Cornelis, Jamieson, Catriona H. M., Wang, Jean Y. J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582213/
https://ncbi.nlm.nih.gov/pubmed/19004799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808303105
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