Effects of single nucleotide polymorphisms in human N-acetyltransferase 2 on metabolic activation (O-acetylation) of heterocyclic amine carcinogens

N-Acetyltransferase 2 (NAT2) catalyzes the O-acetylation of N-hydroxy heterocyclic amines such as N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (N-OH-MeIQx) and N-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (N-OH-PhIP) to DNA binding metabolites that initiate mutagenesis and c...

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Hlavní autoři: Hein, David W., Fretland, Adrian J., Doll, Mark A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582010/
https://ncbi.nlm.nih.gov/pubmed/16570281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.21957
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