A molecular signaling model of platelet phosphoinositide and calcium regulation during homeostasis and P2Y(1) activation

To quantify how various molecular mechanisms are integrated to maintain platelet homeostasis and allow responsiveness to adenosine diphosphate (ADP), we developed a computational model of the human platelet. Existing kinetic information for 77 reactions, 132 fixed kinetic rate constants, and 70 spec...

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Bibliografiske detaljer
Main Authors: Purvis, Jeremy E., Chatterjee, Manash S., Brass, Lawrence F., Diamond, Scott L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2008
Fag:
Hemostasis, Thrombosis, and Vascular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581995/
https://ncbi.nlm.nih.gov/pubmed/18596227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-05-157883
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