NK cell–activating receptors require PKC-θ for sustained signaling, transcriptional activation, and IFN-γ secretion

Natural killer (NK) cell sense virally infected cells and tumor cells through multiple cell surface receptors. Many NK cell–activating receptors signal through immunoreceptor tyrosine–based activation motif (ITAM)–containing adapters, which trigger both cytotoxicy and secretion of interferon-gamma (...

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Autores principales: Tassi, Ilaria, Cella, Marina, Presti, Rachel, Colucci, Angela, Gilfillan, Susan, Littman, Dan R., Colonna, Marco
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2008
Materias:
Immunobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581989/
https://ncbi.nlm.nih.gov/pubmed/18784374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-139527
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