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NK cell–activating receptors require PKC-θ for sustained signaling, transcriptional activation, and IFN-γ secretion
Natural killer (NK) cell sense virally infected cells and tumor cells through multiple cell surface receptors. Many NK cell–activating receptors signal through immunoreceptor tyrosine–based activation motif (ITAM)–containing adapters, which trigger both cytotoxicy and secretion of interferon-gamma (...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2581989/ https://ncbi.nlm.nih.gov/pubmed/18784374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-02-139527 |
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