HBD-3 induces NK Cell activation, IFN-γ secretion and mDC dependent cytolytic function

We previously showed that human beta defensin-3 (hBD-3) activates mDC via TLR1/2. Here we investigated the effects of hBD-3 on NK cell activation state and effector functions. We observed that hBD-3 activates PBMC to secrete IFN-γ and kill K562 and HUH hepatoma target cells in an NK dependent fashio...

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Publicado no:Cell Immunol
Main Authors: Judge, Chelsey J, Reyes-Aviles, Elane, Conry, Sara J, Sieg, Scott S, Feng, Zhimin, Weinberg, Aaron, Anthony, Donald D
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682877/
https://ncbi.nlm.nih.gov/pubmed/26302933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2015.06.004
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