An analysis of the clinical and biologic significance of TP53 loss and the identification of potential novel transcriptional targets of TP53 in multiple myeloma

TP53 is a tumor suppressor gene that functions as transcriptional regulator influencing cellular responses to DNA damage. Here we explored the clinical and transcriptional effects of TP53 expression in multiple myeloma (MM). We found that low expression of TP53, seen in approximately 10% of newly di...

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Hauptverfasser: Xiong, Wei, Wu, Xiaosong, Starnes, Sarah, Johnson, Sarah K., Haessler, Jeff, Wang, Siqing, Chen, Lijuan, Barlogie, Bart, Shaughnessy, John D., Zhan, Fenghuang
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2008
Schlagworte:
Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581979/
https://ncbi.nlm.nih.gov/pubmed/18337559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-10-119123
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