RARα2 expression is associated with disease progression and plays a crucial role in efficacy of ATRA treatment in myeloma

Specific genetic alterations in multiple myeloma (MM) may cause more aggressive diseases. Paired gene array analysis on 51 samples showed that retinoic acid (RA) receptor α (RARα) expression significantly increased at relapse compared with diagnosis. RARα encodes 2 major isoforms: RARα1 and RARα2. I...

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Detalhes bibliográficos
Main Authors: Wang, Siqing, Tricot, Guido, Shi, Lei, Xiong, Wei, Zeng, Zhaoyang, Xu, Hongwei, Zangari, Maurizio, Barlogie, Bart, Shaughnessy, John D., Zhan, Fenghuang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713470/
https://ncbi.nlm.nih.gov/pubmed/19458357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-12-194126
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