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Assembly of the Iron-binding Protein Frataxin in Saccharomyces cerevisiae Responds to Dynamic Changes in Mitochondrial Iron Influx and Stress Level

Defects in frataxin result in Friedreich ataxia, a genetic disease characterized by early onset of neurodegeneration, cardiomyopathy, and diabetes. Frataxin is a conserved mitochondrial protein that controls iron needed for iron-sulfur cluster assembly and heme synthesis and also detoxifies excess i...

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Autori principali: Gakh, Oleksandr, Smith, Douglas Y., Isaya, Grazia
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581586/
https://ncbi.nlm.nih.gov/pubmed/18784075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805415200
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