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Hypermutation at A/T Sites during G·U Mismatch Repair in Vitro by Human B-cell Lysates
Somatic hypermutation in the variable regions of immunoglobulin genes is required to produce high affinity antibody molecules. Somatic hypermutation results by processing G·U mismatches generated when activation-induced cytidine deaminase (AID) deaminates C to U. Mutations at C/G sites are targeted...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2581569/ https://ncbi.nlm.nih.gov/pubmed/18786917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805524200 |
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