Direct Binding of GTP Cyclohydrolase and Tyrosine Hydroxylase: REGULATORY INTERACTIONS BETWEEN KEY ENZYMES IN DOPAMINE BIOSYNTHESIS

The signaling functions of dopamine require a finely tuned regulatory network for rapid induction and suppression of output. A key target of regulation is the enzyme tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis, which is activated by phosphorylation and modulated by the avail...

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Bibliografiske detaljer
Main Authors: Bowling, Kevin M., Huang, Zhinong, Xu, Dong, Ferdousy, Faiza, Funderburk, Christopher D., Karnik, Nirmala, Neckameyer, Wendi, O'Donnell, Janis M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Enzyme Catalysis and Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581565/
https://ncbi.nlm.nih.gov/pubmed/18801743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802552200
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