Crossveinless-2 Is a BMP Feedback Inhibitor that Binds Chordin/BMP to Regulate Xenopus Embryonic Patterning

Vertebrate Crossveinless-2 (CV2) is a secreted protein that can potentiate or antagonize BMP signaling. Through embryological and biochemical experiments we find that: 1) CV2 functions as a BMP4 feedback inhibitor in ventral regions of the Xenopus embryo; 2) CV2 complexes with Twisted gastrulation a...

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Main Authors: Ambrosio, Andrea L., Taelman, Vincent F., Lee, Hojoon X., Metzinger, Carrie, Coffinier, Catherine, De Robertis, E.M.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581521/
https://ncbi.nlm.nih.gov/pubmed/18694564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2008.06.013
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