Binding between Crossveinless-2 and Chordin Von Willebrand Factor Type C Domains Promotes BMP Signaling by Blocking Chordin Activity

BACKGROUND: Crossveinless-2 (CV2) is an extracellular BMP modulator protein of the Chordin family, which can either enhance or inhibit BMP activity. CV2 binds to BMP2 via subdomain 1 of the first of its five N-terminal von Willebrand factor type C domains (VWC1). Previous studies showed that this BM...

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Bibliographic Details
Main Authors: Zhang, Jin-Li, Patterson, Lucy J., Qiu, Li-Yan, Graziussi, Daria, Sebald, Walter, Hammerschmidt, Matthias
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944808/
https://ncbi.nlm.nih.gov/pubmed/20886103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012846
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