Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

Chordin (Chd) is an abundant protein secreted by Spemann organizer tissue during gastrulation. Chd antagonizes signaling by mature bone morphogenetic proteins (BMPs) by blocking binding to their receptors. Recombinant Xenopus Chd binds to BMP-4 with high affinity (K(D) 3 × 10(−10) M), binding specif...

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Main Authors: Piccolo, Stefano, Sasai, Yoshiki, Lu, Bin, De Robertis, Eddy M.
Format: Artigo
Jezik:Inglês
Izdano: 1996
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070603/
https://ncbi.nlm.nih.gov/pubmed/8752213
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