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Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells

We have used the chemotactic ability of Dictyostelium cells to examine the roles of Rho family members, known regulators of the assembly of F-actin, in cell movement. Wild-type cells polarize with a leading edge enriched in F-actin toward a chemoattractant. Overexpression of constitutively active Di...

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Autori principali: Chung, Chang Y., Lee, Susan, Briscoe, Celia, Ellsworth, Charlene, Firtel, Richard A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC25810/
https://ncbi.nlm.nih.gov/pubmed/10805781
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