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Addressing Mechanistic Issues in the Coupling of Isonitriles and Carboxylic Acids: Potential Routes to Peptidic Constructs

[Image: see text] Mechanistic issues surrounding the 2CC (two component coupling) reaction of carboxylic acids with isonitriles have been investigated. Experimental details suggest the FCMA (formimidate carboxylate mixed anhydride) intermediate exists in both interdictable and non-interdictable form...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Li, Xuechen, Yuan, Yu, Kan, Cindy, Danishefsky, Samuel J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2580816/
https://ncbi.nlm.nih.gov/pubmed/18783225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja804709s
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