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Polyglutamine Neurodegeneration: Protein Misfolding Revisited
Polyglutamine diseases are a major cause of neurodegenerative disease worldwide. Recent studies highlight the importance of protein quality control mechanisms in regulating polyglutamine-induced toxicity. Drawing on these studies, we propose a model of disease pathogenesis that integrates current un...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2580745/ https://ncbi.nlm.nih.gov/pubmed/18778858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tins.2008.07.004 |
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