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Deconvoluting the Structural and Drug-Recognition Complexity of the G-Quadruplex-Forming Region Upstream of the bcl-2 P1 Promoter

The human bcl-2 gene contains a GC-rich region upstream of the P1 promoter that has been shown to be critically involved in the regulation of bcl-2 gene expression. We have demonstrated that the guanine-rich strand of the DNA in this region can form any one of three distinct intramolecular G-quadrup...

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Detalhes bibliográficos
Main Authors: Dexheimer, Thomas S., Sun, Daekyu, Hurley, Laurence H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2580050/
https://ncbi.nlm.nih.gov/pubmed/16620112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0563861
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