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A Novel Assay to Trace Proliferation History In Vivo Reveals that Enhanced Divisional Kinetics Accompany Loss of Hematopoietic Stem Cell Self-Renewal

BACKGROUND: The maintenance of lifelong blood cell production ultimately rests on rare hematopoietic stem cells (HSCs) that reside in the bone marrow microenvironment. HSCs are traditionally viewed as mitotically quiescent relative to their committed progeny. However, traditional techniques for asse...

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Autors principals: Nygren, Jens M., Bryder, David
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2580029/
https://ncbi.nlm.nih.gov/pubmed/19002266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003710
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