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A Novel Assay to Trace Proliferation History In Vivo Reveals that Enhanced Divisional Kinetics Accompany Loss of Hematopoietic Stem Cell Self-Renewal

BACKGROUND: The maintenance of lifelong blood cell production ultimately rests on rare hematopoietic stem cells (HSCs) that reside in the bone marrow microenvironment. HSCs are traditionally viewed as mitotically quiescent relative to their committed progeny. However, traditional techniques for asse...

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Autori principali: Nygren, Jens M., Bryder, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2580029/
https://ncbi.nlm.nih.gov/pubmed/19002266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003710
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