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A Novel Assay to Trace Proliferation History In Vivo Reveals that Enhanced Divisional Kinetics Accompany Loss of Hematopoietic Stem Cell Self-Renewal

BACKGROUND: The maintenance of lifelong blood cell production ultimately rests on rare hematopoietic stem cells (HSCs) that reside in the bone marrow microenvironment. HSCs are traditionally viewed as mitotically quiescent relative to their committed progeny. However, traditional techniques for asse...

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מידע ביבליוגרפי
Main Authors: Nygren, Jens M., Bryder, David
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2580029/
https://ncbi.nlm.nih.gov/pubmed/19002266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003710
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