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APC Activation Restores Functional CD4(+)CD25(+) Regulatory T Cells in NOD Mice that Can Prevent Diabetes Development
BACKGROUND: Defects in APC and regulatory cells are associated with diabetes development in NOD mice. We have shown previously that NOD APC are not effective at stimulating CD4(+)CD25(+) regulatory cell function in vitro. We hypothesize that failure of NOD APC to properly activate CD4(+)CD25(+) regu...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2580026/ https://ncbi.nlm.nih.gov/pubmed/19011680 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003739 |
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