Reduction of DILP2 in Drosophila Triages a Metabolic Phenotype from Lifespan Revealing Redundancy and Compensation among DILPs

The insulin/IGF-like signalling (IIS) pathway has diverse functions in all multicellular organisms, including determination of lifespan. The seven insulin-like peptides (DILPs) in Drosophila are expressed in a stage- and tissue-specific manner. Partial ablation of the median neurosecretory cells (mN...

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Main Authors: Broughton, Susan, Alic, Nazif, Slack, Cathy, Bass, Timothy, Ikeya, Tomoatsu, Vinti, Giovanna, Tommasi, Anna Maria, Driege, Yasmine, Hafen, Ernst, Partridge, Linda
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579582/
https://ncbi.nlm.nih.gov/pubmed/19005568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003721
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