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Human domain antibodies to conserved sterically restricted regions on gp120 as exceptionally potent cross-reactive HIV-1 neutralizers

The antibody access to some conserved structures on the HIV-1 envelope glycoprotein (Env) is sterically restricted. We have hypothesized that the smallest independently folded antibody fragments (domains) could exhibit exceptionally potent and broadly cross-reactive neutralizing activity by targetin...

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Main Authors: Chen, Weizao, Zhu, Zhongyu, Feng, Yang, Dimitrov, Dimiter S.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579388/
https://ncbi.nlm.nih.gov/pubmed/18957538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805297105
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