TRANSLOCATION OF IRON FROM LYSOSOMES INTO MITOCHONDRIA IS A KEY EVENT DURING OXIDATIVE STRESS-INDUCED HEPATOCELLULAR INJURY

Iron overload exacerbates various liver diseases. In hepatocytes, a portion of non-heme iron is sequestered in lysosomes and endosomes. The precise mechanisms by which lysosomal iron participates in hepatocellular injury remain uncertain. Here, our aim was to determine the role of intracellular move...

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Hauptverfasser: Uchiyama, Akira, Kim, Jae-Sung, Kon, Kazuyoshi, Jaeschke, Hartmut, Ikejima, Kenichi, Watanabe, Sumio, Lemasters, John J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579320/
https://ncbi.nlm.nih.gov/pubmed/18846543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22498
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